Today's edition of quick hits:* Charlotte: "The armed man fatally shot by North Carolina cops Tuesday was given multiple warnings to drop his weapon, police officials said in the wake of violent late-night clashes between law enforcement and protesters."* Climate crisis: "A global climate agreement moved closer toward taking effect by the end of the year, as 30 more nations ratified it Wednesday during a special meeting on the sidelines of the United Nations General Assembly."* Syria: "Secretary of State Kerry said he sometimes feels like he's living in a 'parallel universe' to his Russian counterpart on the subject of Syria. During an impassioned address at a United Nations Security Council briefing on the five-year civil war Wednesday, he also argued that a cease-fire deal brokered by the U.S. and Russia on September 9 could be saved in spite of a string of violations."* ISIS is facing the prospect of losing Mosul -- and as a consequence, it's lashing out in desperation.* A divided Federal Reserve today "left its policy rate unchanged for a sixth straight meeting, saying it would wait for more evidence of progress toward its goals, while projecting that an increase is still likely by year-end."* Quite a scandal in Iowa: "A staffer from Ron Paul's 2012 presidential campaign is headed to prison for his role in a conspiracy that falsified Federal Election Commission reports. Unlike his two co-defendants who only got probation, Dimitri Kesari will serve three months behind bars."* EpiPen: "Lawmakers chastised EpiPen's chief executive for amassing an $18 million salary during a contentious congressional hearing Wednesday afternoon, as she evaded questions about how much profit the company made off the lifesaving allergy drug."* Nieto's bad idea: "Three quarters of Mexicans consider President Enrique Pena Nieto's invitation and reception of Donald Trump last month to have been inappropriate, with the meeting ranking as the biggest mistake of his three years in office, according to a poll released Wednesday."Anything to add? Consider this an open thread.