Griffin announced her departure Thursday in a posting on her Twitter account, which was verified by her office.
The comedian said she has discovered that her style does not fit with the E! channel show’s “creative direction” and that it’s time for her to move on. She had replaced the late Joan Rivers, who Griffin called her “beloved friend.”
Osbourne exited “Fashion Police” two weeks ago, just after complaining about co-host Giuliana Rancic’s red-carpet criticism of singer-actress Zendaya’s dreadlocks.
In a statement, the channel thanked Griffin for her work and said the show will return as scheduled on March 30 with executive producer Melissa Rivers joining remaining hosts Rancic and Brad Goreski.